The pathogenesis of Sjögren's syndrome involves the activation of NF-κB, producing proinflammatory cytokines such as tumor necrosis factor-α, interleukin (IL)-1α, IL-1β, IL-6, IL-17, and interferon-γ. Through oxidative stress, they will cause necrosis and apoptosis of lacrimal gland cells, resulting in impaired secretory function or reduced tear production. Moringa oleifera leaf extract is known to have strong anti-inflammatory and antioxidant activities.