Cancer is caused by uncontrolled cell growth and
angiogenesis as a vital component in tumor growth and metastasis.
Angiogenesis provides nutrients needed by cancer cells in order to
grow. Angiogenesis is triggered by pro-angiogenic mediators and
overexpression of these mediators have been associated with malignant
phenotype of ovarian cancer. It is thought that the more advanced tumors
have higher tumor cell survival, proliferation, invasion, and angiogenesis,
so that it will show higher expression of pro-angiogenesis mediators.